Clinical Conversation in Interventional Cardiology - Updates from ACC.25 on PE: New Data From the REAL-PE II and OPTALYSE 3D Studies-Clinical Conversation in Interventional Cardiology - Updates from ACC.25 on PE: New Data From the REAL-PE II and OPTALYSE 3D Studies

Clinical Conversation in Interventional Cardiology - Updates from ACC.25 on PE: New Data From the REAL-PE II and OPTALYSE 3D Studies

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Video Transcription

Video Summary

The video transcript features a clinical discussion on new research in pulmonary embolism (PE) therapies, led by Jay Geary from the University of Pennsylvania. The session presents recent data from two significant studies: the Real PE study, introduced by Peter Monteleone, and the Optalyse 3D research, presented by Greg Piazza. <br /><br />Real PE evaluates the safety of ultrasound-assisted catheter-directed thrombolysis and mechanical thrombectomy using the Truvada dataset, which contains extensive electronic health records for over 120 million U.S. patients. The study found that ultrasound-assisted catheter-directed thrombolysis had lower bleeding rates compared to mechanical thrombectomy. Real PE2 further refined these results with up-to-date data and exact matching methodologies.<br /><br />Optalyse 3D focuses on the efficacy of ultrasound-facilitated catheter-based fibrinolysis by exploring pulmonary venous changes rather than proximal thrombus resolution. It highlights the importance of distal pulmonary changes in enhancing gas exchange. <br /><br />A panel discussion follows, featuring experts like June Lee and Rob Lookstein, who discuss the implications of these findings, emphasizing the necessity of further research and trials to determine the optimal PE treatment strategies, particularly in intermediate-risk patients. The session underscores the value of multi-faceted, real-world data to guide future clinical decisions and trial designs.

Keywords

pulmonary embolism

thrombolysis

mechanical thrombectomy

ultrasound-assisted

Real PE study

Optalyse 3D

clinical research