Management of Shock in Patients With Pulmonary Embolism-Questions Remaining Unanswered in Published Thrombectomy Trials, Where Do We Go from Here? Dr. Said Ashraf

Questions Remaining Unanswered in Published Thrombectomy Trials, Where Do We Go from Here? Dr. Said Ashraf

Video Transcription

Video Summary

Dr. Oster discusses a complex case of a 59-year-old woman with pulmonary embolism (PE) and splenic injury, treated successfully with catheter-directed thrombectomy (CDT) and ECMO support. Highlighting the evolving landscape of PE treatment, he notes recent trials (FLAME, PEERLESS2, SYMPHONYPE) showing benefits of mechanical thrombectomy, particularly in intermediate-risk PE. Current guidelines favor thrombolysis for high-risk PE, but ongoing trials (PERSEVERE, STORM-PE) aim to clarify CDT’s role and optimal patient selection. Key unresolved issues include timing, device choice, long-term outcomes, and implications for high-risk patients. CDT is promising but requires further research to define its full potential.

Keywords

pulmonary embolism

catheter-directed thrombectomy

ECMO support

mechanical thrombectomy trials

PE treatment guidelines