SCAI 2026 Angio-Derived Physiology: Data, Technology, and Clinical Integration-ALL-RISE Clinical Insights and Case Examples, Dr. Al-Azizi

ALL-RISE Clinical Insights and Case Examples, Dr. Al-Azizi

Video Transcription

Video Summary

The speaker presented the ALDRYS trial, which tested whether an AI-based system that estimates coronary physiology from routine angiograms is as safe and effective as wire-based FFR or non-hyperemic pressure ratio measurements. In 1,900 patients, the software was non-inferior at one year, with similar MACE, shorter assessment and procedure times, less fluoroscopy, and lower contrast use. Limitations included exclusion of CABG patients and a mixed control group. A case example showed how the technology helped identify ischemia and guide PCI, with reassuring post-PCI physiology results.

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Keywords

ALDRYS trial

AI-based coronary physiology

fractional flow reserve

non-inferiority study

percutaneous coronary intervention