SCAI 2026 Sirolimus-Eluting Balloons in Coronary PCI: Key Insights from Recent Evidence-Discussion 2: Clinical Implications, Current Gaps and Challenges, and Key Takeaways

Discussion 2: Clinical Implications, Current Gaps and Challenges, and Key Takeaways

Video Transcription

Video Summary

Experts debated drug-coated balloons (DCBs) versus drug-eluting stents for in-stent restenosis and de novo lesions. The key message: DCB success depends on excellent lesion preparation, imaging, and final vessel result, not just the drug itself. Multiple devices may be needed before DCB use. DCBs were favored for ISR, complex bifurcations, and some left main/ostial circumflex cases to avoid adding metal layers. DES may slightly outperform DCBs at one year, but long-term strategy and repeat restenosis risk matter. The panel stressed open-mindedness, better preparation, and continued trials to define DCB’s role.

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Keywords

drug-coated balloons

drug-eluting stents

in-stent restenosis

lesion preparation

coronary interventions