SCAI 2026 Sirolimus-Eluting Balloons in Coronary PCI: Key Insights from Recent Evidence-Review of SELUTION4ISR Trial, Dr. Cutlip

Review of SELUTION4ISR Trial, Dr. Cutlip

Video Transcription

Video Summary

The speaker reviewed the SOLUTION ISR trial comparing a sirolimus drug-eluting balloon (DEB) with usual care for in-stent restenosis. Patients underwent mandatory lesion pretreatment and imaging, then were randomized to DEB or operator-chosen control (mostly drug-eluting stents, some balloon angioplasty). DEB was non-inferior to standard care for target lesion failure at 12 months, with similar safety outcomes. In single-layer ISR, drug-eluting stents showed numerically better results than DEB, but DEB avoids adding another stent layer. Longer-term follow-up will help define the best strategy.

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Keywords

SOLUTION ISR trial

sirolimus drug-eluting balloon

in-stent restenosis

target lesion failure

drug-eluting stents