SCAI 2026 Workshop on the Treatment of Pulmonary Embolism-Advanced Therapies in Acute Pulmonary Embolism - Matching Risk, Indication, and Evidence, Dr. Li

Advanced Therapies in Acute Pulmonary Embolism - Matching Risk, Indication, and Evidence, Dr. Li

Video Transcription

Video Summary

The speaker explains how PE guidelines apply to treatment decisions. Lower-risk patients are generally managed with anticoagulation, while advanced therapies like catheter-directed lysis or mechanical thrombectomy are more strongly supported in sicker patients, especially D1/D2 and E1/E2. For intermediate-risk C2/C3 patients, the benefit over anticoagulation remains uncertain. Newer trials suggest mechanical thrombectomy may improve RV/LV ratio, function, and possibly clinical outcomes, but head-to-head comparisons are still lacking. Two cases illustrate how clot burden, biomarker elevation, RV strain, and clot-in-transit can influence choosing advanced therapy.

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Keywords

pulmonary embolism

anticoagulation

mechanical thrombectomy

right ventricular strain

catheter-directed therapy