SCAI 2026 Workshop on the Treatment of Pulmonary Embolism-Up-to-Date Landscape of PE Data, Dr. Giri

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Video Summary

The speaker reviews three recent randomized pulmonary embolism trials. PEERLESS compared catheter-directed thrombolysis with large-bore mechanical thrombectomy in 550 intermediate-risk patients and found no major differences in mortality or major bleeding, though thrombectomy shortened ICU stay and reduced crossover/bailout. A smaller trial of 100 patients showed Penumbra aspiration thrombectomy improved RV/LV ratio, tachycardia, and oxygenation versus anticoagulation alone. The most important study, HiPIT, randomized 544 selected patients to anticoagulation versus catheter-directed lysis with ECOS and found a significant benefit in a composite outcome, especially preventing cardiorespiratory decompensation, supporting more aggressive PE treatment.

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Keywords

pulmonary embolism

catheter-directed thrombolysis

mechanical thrombectomy

anticoagulation

right ventricular function