Targeting Inflammation in Atherosclerotic Disease - The New Frontier-Unlocking the Story of Colchicine and Its Role in the Treatment of Coronary Artery Disease, Dr. Binita Shah

Unlocking the Story of Colchicine and Its Role in the Treatment of Coronary Artery Disease, Dr. Binita Shah

Video Transcription

Video Summary

The presentation discussed the role of colchicine in cardiovascular disease, focusing on its effects on inflammation. Colchicine, known for its historical use in rheumatism, affects neutrophils by inhibiting L-selectin, reducing inflammation and potentially stabilizing plaques. Studies indicate colchicine can lower CRP levels and may reduce recurrent myocardial infarctions, particularly in high-risk and stable CAD patients. However, routine use, especially post-STEMI, is not universally beneficial. Adverse effects are mainly gastrointestinal. Further research, including trials on optimal dosing and patient selection, is necessary to clarify colchicine’s role.

Keywords

colchicine

cardiovascular disease

inflammation

myocardial infarctions

gastrointestinal effects