Workshop on the Treatment of Pulmonary Embolism-PEERLESS-II and PERSEVERE, Dr. Jay Giri

PEERLESS-II and PERSEVERE, Dr. Jay Giri

Video Transcription

Video Summary

The discussion revolves around the STORM-PE and PLS2 trials. Rachel Rosofsky, an expert on venous thromboembolism, was highlighted as a strong leader for STORM-PE. Enrollment has been nearly equal for men and women, which is unusual for cardiovascular trials. PLS2 focuses on large-bore mechanical thrombectomy versus anticoagulation in PE patients, using a diverse steering committee for international and specialty representation. Its hierarchical composite endpoint uses a win ratio to enhance statistical power and outcome analysis. The forthcoming Persevere trial faces challenges in enrolling high-risk PE patients, aiming for a sample of 200 patients.

Keywords

STORM-PE

venous thromboembolism

PLS2 trial

mechanical thrombectomy

Persevere trial