Conversations in Interventional Cardiology: Novel Aspiration Thrombectomy and Blood Reinfusion System for Acute Intermediate-Risk Pulmonary Embolism-Novel Aspiration Thrombectomy and Blood Reinfusion System for Acute Intermediate-Risk Pulmonary Embolism

Novel Aspiration Thrombectomy and Blood Reinfusion System for Acute Intermediate-Risk Pulmonary Embolism

Video Transcription

Video Summary

The discussion reviewed the VENTUS trial of a novel aspiration thrombectomy and blood reinfusion system for intermediate-risk pulmonary embolism. The multicenter single-arm study enrolled 120 patients at 22 sites and showed strong procedural efficiency, including low blood loss, no transfusions, short catheter dwell times, and successful blood return in most cases. The trial met its primary efficacy endpoint with significant reduction in RV/LV ratio and clot burden, as well as its safety endpoint with no device-related adverse events. Uniquely, it also included functional outcomes, showing improved quality of life and a marked increase in 6-minute walk distance at 30 days. Panelists highlighted device features such as a beveled tip, easier branch access, and an automated closed-loop blood return system, emphasizing safety, simplicity, and broader usability. They concluded that PE thrombectomy is evolving rapidly, with guidelines and newer devices helping shape more personalized treatment.

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Keywords

VENTUS trial

pulmonary embolism thrombectomy

aspiration thrombectomy

blood reinfusion system

right ventricular ratio reduction